Type I Diabetes is a result of immunological destruction of pancreatic beta-cells, while Type 2 Diabetes is the combination of impairment of insulin-mediated glucose disposal and defective secretion of insulin by pancreatic beta-cells. Common models for evaluating diabetic conditions include spontaneous models and chemically induced models.


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Diabetes Type I

Type I diabetes can be induced in rodents by the injection of the chemical, streptozotocin (STZ), which destroys insulin producing cells in the pancreas. Hyperglycaemia ensues within four weeks of the STZ administration.

Diabetes Type II

Type II diabetic models are available using either genetically altered animal strains prone to this pathology (Db/db mice or Zucker Diabetic Fatty fa/fa rats) or in wild type mice using high fat diets.

Diabetic Kidney Ischemia

Diabetic kidney ischaemia is achieved by temporary surgical obstruction of either renal pedicles in Type I or Type II diabetic animals (see above).


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Please contact us for more information on any of these models, to obtain a proposal or to arrange to speak with one of our scientists.


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