Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) is a group of inflammatory conditions of the colon and small intestine. The major types are Ulcerative Colitis (UC) and Crohn’s Disease (CD). Human IBD is a chronic remitting/relapsing inflammatory condition of unknown origin that affects an estimated 3-4 million patients in Europe and the U.S.
FEATURED DISEASE MODELS:
Inflammatory Bowel Disease (IBD) – Acute TNBS Colitis
Colonic inflammation is induced by the intra-colonic instillation of the hapten, trinitrobenzene sulphonic acid and the extent of inflammation assessed after 3 days by visual measurement and/or histological evaluation, with experimental treatment commencing prior to challenge.
Inflammatory Bowel Disease (IBD) – Chronic TNBS Colitis
Colonic inflammation is induced by the intra-colonic instillation of the hapten, trinitrobenzene sulphonic acid and the extent of inflammation assessed 14 or 21 days later by visual measurement and/or histological evaluation, with experimental treatment commencing 24 hours following challenge.
DSS Colitis
Intestinal inflammation is induced by administering 5% dextran sulphate sodium in drinking water, which disrupts the epithelial monolayer resulting in exposure of the underlying immune system to the intestinal microbiota.
