molecules

Inflammatory Bowel Disease

Inflammatory Bowel Disease (IBD) is a group of inflammatory conditions of the colon and small intestine. The major types are Ulcerative Colitis (UC) and Crohn’s Disease (CD). Human IBD is a chronic remitting/relapsing inflammatory condition of unknown origin that affects an estimated 3-4 million patients in Europe and the U.S.

 

disorder image

 

FEATURED DISEASE MODELS:

Inflammatory Bowel Disease (IBD) – Acute TNBS Colitis

Colonic inflammation is induced by the intra-colonic instillation of the hapten, trinitrobenzene  sulphonic acid and the extent of inflammation assessed after 3 days by visual measurement and/or histological evaluation, with experimental treatment commencing prior to challenge.

Inflammatory Bowel Disease (IBD) – Chronic TNBS Colitis

Colonic inflammation is induced by the intra-colonic instillation of the hapten, trinitrobenzene  sulphonic acid and the extent of inflammation assessed 14 or 21 days later by visual measurement and/or histological evaluation, with experimental treatment commencing 24 hours following challenge.

DSS Colitis

Intestinal inflammation is induced by administering 5% dextran sulphate sodium in drinking water, which disrupts the epithelial monolayer resulting in exposure of the underlying immune system to the intestinal microbiota.

memorial

Interested in starting research with us?

Please contact us for more information on any of these models, to obtain a proposal or to arrange to speak with one of our scientists.

CONTACT US

Website design and development by Adept Lab photography by: Gary Schwartz