research models

Our research models

William Harvey Research Ltd (WHRL) is a preclinical contract research organisation who has been working with Biotech and Pharmaceutical sectors since 1990. A primary aim of WHRL is to co-ordinate contract research as an Efficacy, Verification and Interpretation Service (EVIS).

With a catalogue of more than 120 in vivo and in vitro models available alongside flexible experimental design and expert advice from our Lead Scientists at the William Harvey Research Institute, we aim to deliver excellent standards of research.

Our research falls into the following categories:



The development of new anti-inflammatory therapeutics usually entails the assessment of drug efficacy in disease models. We offer a vast series of validated models, as well as more sophisticated approaches to assess the anti-inflammatory potential of new candidates.



Renal disease (also known as kidney disease), represent a broad class of diseases caused by damages/abnormalities of the kidney, which can elicit many severe clinical symptoms. We offer disease models for Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), and Unilateral Ureteral Obstruction (UUO).



Sepsis is primarily described as a state of disrupted inflammatory homeostasis that is often initiated by infection. Severe sepsis is organ failure in the setting of sepsis and septic shock is organ failure where sepsis is hypotensive. Bacteria (such as LPS) is used to induce sepsis, setting off an immune response activating immune cells that excrete cytokines. 


Pulmonary Hypertension

Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure within the arteries of the lungs. Our models span the analysis of tissue injury in the heart, the kidneys, as well as the liver. Early stage development of new cardiovascular therapeutics frequently necessitates the evaluation of drug efficacy in disease models



Type I Diabetes is a result of immunological destruction of pancreatic beta-cells, while Type 2 Diabetes is the combination of impairment of insulin-mediated glucose disposal and defective secretion of insulin by pancreatic beta-cells. Common models for evaluating diabetic conditions include spontaneous models and chemically induced models.


Inflammatory Bowel Disease

Inflammatory Bowel Disease (IBD) is a group of inflammatory conditions of the colon and small intestine.  The major types are Ulcerative Colitis (UC) and Crohn’s Disease (CD). Human IBD is a chronic remitting/relapsing inflammatory condition.



Nociception is the detection of painful stimuli. Pain perception follows the transmission of nociceptive signals through the peripheral and central nervous system. Acute pain generally resolves with the healing of tissue or nerve damage, whereas chronic pain is pathological and is driven by plastic changes in the nervous system . In rodent models of acute and chronic pain, we can measure pain and sensory function using behaviour assays, in vivo electrophysiology and in vitro methods.


Commissioning studies

If you are looking to commission an upcoming study and would like to see how WHRL could help you, we’d love to hear from you.

Please contact us for a proposal or to speak to one of our scientists about your study requirements.


research models

Three reasons why you should choose WHRL

We offer an expert team of scientists based at the world-renowned William Harvey Research Institute in London, with 20 years of experience in preclinical drug discovery – we have worked with more than 100 companies.

We have one of the broadest catalogues of disease models and techniques available covering therapeutic areas such as arthritis, myocardial infarction, diabetes, multiple sclerosis.

You will receive one-to-one discussions and advice on your preclinical testing needs, available directly from your Lead Scientist.


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