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Pulmonary Hypertension

Pulmonary hypertension (PH) is a condition of increased blood pressure within the arteries of the lungs which results in pulmonary vascular remodelling and right ventricular hypertrophy & failure. Our models span the analysis of tissue injury in the lungs and heart. Early stage development of new cardiovascular therapeutics frequently necessitates the evaluation of drug efficacy in disease models.

 

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FEATURED DISEASE MODELS:

Pulmonary Hypertension

This is the gold standard pre-clinical model of PH and combines exposure to hypoxia (10% O2) with administration of the VEGFR2 antagonist, Sugen. This approach recapitulates many aspects of the human disease, producing a robust increase in pulmonary artery pressure, pulmonary small artery remodelling, and right ventricular hypertrophy/dysfunction.

Pulmonary Fibrosis (Bleomycin)

The chemotherapeutic drug bleomycin causes a severe inflammation-driven pulmonary fibrosis that is accompanied by secondary PH (akin to that produced by hypoxia/Sugen, albeit less severe).

 

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Interested in starting research with us?

Please contact us for more information on any of these models, to obtain a proposal or to arrange to speak with one of our scientists.

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